Therapeutic approaches to potassium disorders

Authors

  • Percy Herrera-Añazco Hospital Nacional Dos de Mayo, Lima, Perú. Universidad Privada del Norte, Trujillo, Perú
  • Andrea C. Rivas-Nieto Hospital Nacional Cayetano Heredia, Lima, Perú
  • Domingo Chang-Davila Hospital Nacional Dos de Mayo, Lima, Perú
  • Juan Lluncor Vasquez Hospital Nacional Dos de Mayo, Lima, Perú

DOI:

https://doi.org/10.35434/rcmhnaaa.2023.164.1924

Keywords:

Potassium, Hyperkalemia, Hypokalemia, Emergencies

Abstract

Potassium is an essential cation for multiple physiological processes and potassium disorders, also known as dyskalemias, imply an increased risk of cardiovascular and neurological complications. The present review aims to outline the main strategies for the management of patients with potassium disorders in the hospital setting. For the management of hyperkalemia, we propose that the therapeutic approach should include etiologic evaluation, evidence-based pharmacologic management, monitoring of therapeutic response, and timely decision on initiation of dialysis. For hypokalemia, we suggest initial assessment of severity, pharmacologic management, and monitoring of response to therapy. Despite the limitations of the primary evidence for the management of potassium disorders, the present recommendations emphasize practices based on the best available evidence.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Percy Herrera-Añazco, Hospital Nacional Dos de Mayo, Lima, Perú. Universidad Privada del Norte, Trujillo, Perú

1. Médico Nefrólogo

2. Magister en Docencia en Educación Superior

Andrea C. Rivas-Nieto, Hospital Nacional Cayetano Heredia, Lima, Perú

1. Médico nefrólogo

Domingo Chang-Davila, Hospital Nacional Dos de Mayo, Lima, Perú

1. Médico nefrólogo

Juan Lluncor Vasquez, Hospital Nacional Dos de Mayo, Lima, Perú

1. Médico nefrólogo

References

Gumz ML, Rabinowitz L, Wingo CS. An Integrated View of Potassium Homeostasis. N Engl J Med. 2015;373(1):60-72. doi: 10.1056/NEJMra1313341.

Palmer BF, Clegg DJ. Physiology and Pathophysiology of Potassium Homeostasis: Core Curriculum 2019. Am J Kidney Dis. 2019;74(5):682-695. doi: 10.1053/j.ajkd.2019.03.427.

Faxén J, Xu H, Evans M, Jernberg T, Szummer K, Carrero JJ. Potassium levels and risk of in-hospital arrhythmias and mortality in patients admitted with suspected acute coronary syndrome. Int J Cardiol. 2019;274:52-58. doi: 10.1016/j.ijcard.2018.09.099

Conway R, Creagh D, Byrne DG, O'Riordan D, Silke B. Serum potassium levels as an outcome determinant in acute medical admissions. Clin Med (Lond). 2015;15(3):239-43. doi: 10.7861/clinmedicine.15-3-239.

Fleet JL, Shariff SZ, Gandhi S, Weir MA, Jain AK, Garg AX. Validity of the International Classification of Diseases 10th revision code for hyperkalaemia in elderly patients at presentation to an emergency department and at hospital admission. BMJ Open. 2012;2(6):e002011. doi: 10.1136/bmjopen-2012-002011.

Singer AJ, Thode HC Jr, Peacock WF. A retrospective study of emergency department potassium disturbances: severity, treatment, and outcomes. Clin Exp Emerg Med. 2017;4(2):73-79. doi: 10.15441/ceem.16.194.

Arampatzis S, Funk GC, Leichtle AB, Fiedler GM, Schwarz C, Zimmermann H, et al. Impact of diuretic therapy-associated electrolyte disorders present on admission to the emergency department: a cross-sectional analysis. BMC Med. 2013;11:83. doi: 10.1186/1741-7015-11-83

Lindner G, Burdmann EA, Clase CM, Hemmelgarn BR, Herzog CA, Małyszko J, et al. Acute hyperkalemia in the emergency department: a summary from a Kidney Disease: Improving Global Outcomes conference. Eur J Emerg Med. 2020;27(5):329-337. doi: 10.1097/MEJ.0000000000000691.

Palmer BF, Carrero JJ, Clegg DJ, Colbert GB, Emmett M, Fishbane S, et al. Clinical Management of Hyperkalemia. Mayo Clin Proc. 2021;96(3):744-762. doi: 10.1016/j.mayocp.2020.06.014.

Jensen HK, Brabrand M, Vinholt PJ, Hallas J, Lassen AT. Hypokalemia in acute medical patients: risk factors and prognosis. Am J Med. 2015;128(1):60-7.e1. doi: 10.1016/j.amjmed.2014.07.022

Mattsson N, Nielsen OW, Johnson L, Prescott E, Schnohr P, Jensen GB, et al. Prognostic Impact of Mild Hypokalemia in Terms of Death and Stroke in the General Population-A Prospective Population Study. Am J Med. 2018;131(3):318.e9-318.e19. doi: 10.1016/j.amjmed.2017.09.026.

Thirumal V, Love G. Hypokalaemia: Addressing human factors and improving education around prescription and administration of

Intravenous (IV) Potassium infusion in Trauma and Orthopaedics. BMJ Qual Improv Rep. 2017;6(1):u213676.w7336. doi: 10.1136/bmjquality.u213676.w7336.

Ota Y, Obata Y, Takazono T, Tashiro M, Wakamura T, Takahashi A, et al. Association between potassium supplementation and the occurrence of acute kidney injury in patients with hypokalemia administered liposomal amphotericin B: a nationwide observational study. BMC Nephrol. 2021;22(1):240. doi: 10.1186/s12882-021-02450-7.

Meza Huamán A, Cieza Zevallos JA. Frecuencia y características de las alteraciones electrolíticas en pacientes hospitalizados en servicios de Medicina en un hospital general. Rev Medica Hered. 2016;27(4):237–42. http://dx.doi.org/10.20453/rmh.v27i4.2993

Alfano G, Ferrari A, Fontana F, Perrone R, Mori G, Ascione E, et al. Hypokalemia in Patients with COVID-19. Clin Exp Nephrol. 2021;25(4):401–9. doi: 10.1007/s10157-020-01996-4

Tazmini K, Nymo SH, Louch WE, Ranhoff AH, Øie E. Electrolyte imbalances in an unselected population in an emergency department: A retrospective cohort study. Lazzeri C, editor. PLOS ONE. 2019;14(4):e0215673. doi: 10.1371/journal.pone.0215673

Crop MJ, Hoorn EJ, Lindemans J, Zietse R. Hypokalaemia and subsequent hyperkalaemia in hospitalized patients. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc. 2007;22(12):3471–7. doi: 10.1093/ndt/gfm471.

Wang Y, Hu J, Geng X, Zhang X, Xu X, Lin J, et al. A novel scoring system for assessing the severity of electrolyte and acid-base disorders and predicting outcomes in hospitalized patients. J Investig Med Off Publ Am Fed Clin Res. 2019;67(4):750–60. oi: 10.1136/jim-2018-000900.

Kardalas E, Paschou SA, Anagnostis P, Muscogiuri G, Siasos G, Vryonidou A. Hypokalemia: a clinical update. Endocr Connect. 2018;7(4):R135–46. doi: 10.1530/EC-18-0109.

León-Zuloeta R, Chávez-Pasco GS, Loza-Munarriz C, León-Zuloeta R, Chávez-Pasco GS, Loza-Munarriz C. Alteraciones del equilibrio acido base y electrolíticas en pacientes con crisis hiperglicémica atendidos en emergencia de un hospital general de Chiclayo. Rev Medica Hered. 2020;31(3):155–63. http://dx.doi.org/10.20453/rmh.v31i3.3804.

Gupta AA, Self M, Mueller M, Wardi G, Tainter C. Dispelling myths and misconceptions about the treatment of acute hyperkalemia. Am J Emerg Med. 2022;52:85–91. doi: 10.1016/j.ajem.2021.11.030

Palmer BF, Clegg DJ. Hyperkalemia across the Continuum of Kidney Function. Clin J Am Soc Nephrol. 2018;13(1):155–7. doi: 10.2215/CJN.09340817.

Wrenn KD, Slovis CM, Slovis BS. The ability of physicians to predict hyperkalemia from the ECG. Ann Emerg Med. 1991;20(11):1229-32. doi: 10.1016/s0196-0644(05)81476-3.

Rafique Z, Aceves J, Espina I, Peacock F, Sheikh-Hamad D, Kuo D. Can physicians detect hyperkalemia based on the electrocardiogram? Am J Emerg Med. 2020;38(1):105–8. doi: 10.1016/j.ajem.2019.04.036.

Batterink J, Cessford TA, Taylor RA. Pharmacological interventions for the acute management of hyperkalaemia in adults. Cochrane Database Syst Rev. 2015;10(10):CD010344. doi: 10.1002/14651858

Varallo FR, Trombotto V, Lucchetta RC, Mastroianni PC. Efficacy and safety of the pharmacotherapy used in the management of hyperkalemia: a systematic review. Pharm Pract. 2019;17(1):1361. doi: 10.18549/PharmPract.2019.1.1361.

Peacock WF, Rafique Z, Clark CL, Singer AJ, Turner S, Miller J, et al. Real World Evidence for Treatment of Hyperkalemia in the Emergency Department (REVEAL–ED): A Multicenter, Prospective, Observational Study. J Emerg Med. 2018;55(6):741–50. doi: 10.1016/j.jemermed.2018.09.007

Herrera Añazco P, Palacios Guillén M, Chipayo Gonzales D, Barrenechea Gómez M, Silveira Chau M. Manejo de hiperkalemia en la emergencia de un hospital general. An Fac med [Internet]. 2014 Abr [citado 23 enero 2023];75(2):201-2. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1025-55832014000200021&lng=es.

Elliott TL, Braun M. Electrolytes: Potassium Disorders. FP Essent. 2017 [cited 2023 feb 3];459:21–8. Available from: https://pubmed.ncbi.nlm.nih.gov/28806047/.

Inzar-Santana S, Kawano-Soto CA, Dehesa-Lopez E, López-Ceja M. Hiperkalemia: Artículo de revisión. Rev Med UAS [Internet]. Julio-Setiembre [citado 16 febrero 2023];6(3). Disponible en: https://hospital.uas.edu.mx/revmeduas/pdf/v6/n3/hiperkalemia.pdf

Cohn JN, Kowey PR, Whelton PK, Prisant LM. New guidelines for potassium replacement in clinical practice: a contemporary review by the National Council on Potassium in Clinical Practice. Arch Intern Med. 2000;160(16):2429–36. doi: 10.1001/archinte.160.16.2429.

Asmar A, Mohandas R, Wingo CS. A Physiologic-Based Approach to the Treatment of a Patient With Hypokalemia. Am J Kidney Dis. 2012;60(3):492–7. doi: 10.1053/j.ajkd.2012.01.031.

del Río Crespo ÉA, Granda Carvajal PA, Castañeda Garcés SA. Experiencia con la implementación del uso de soluciones estandarizadas de cloruro de potasio. Av En Enferm. 2015;33(1):19–28. doi: http://dx.doi.org/10.15446/av.enferm.v33n1.48648

Weiner ID, Wingo CS. Hypokalemia--consequences, causes, and correction. J Am Soc Nephrol. 1997;8(7):1179. doi: 10.1681/ASN.V871179.

Chalwin RP, Moran JL, Peake SI, Flynn S, Pieterse J, Williams P. Assessing the performance of a continuous infusion for potassium supplementation in the critically ill. Anaesth Intensive Care. 2012;40(3):433–41. doi: 10.1177/0310057X1204000308.

Sterns RH, Cox M, Feig PU, Singer I. Internal potassium balance and the control of the plasma potassium concentration. Medicine (Baltimore). 1981;60(5):339–54. doi: 10.1097/00005792-198109000-00002

Pichitporn W, Kanjanabuch T, Phannajit J, Puapatanakul P, Chuengsaman P, Parapiboon W, et al. Efficacy of Potassium Supplementation in Hypokalemic Patients Receiving Peritoneal Dialysis: A Randomized Controlled Trial. Am J Kidney Dis Off J Natl Kidney Found. 2022;80(5):580-588. doi: 10.1053/j.ajkd.2022.03.013.

Wuermser LA, Reilly C, Poindexter JR, Sakhaee K, Pak CY. Potassium-magnesium citrate versus potassium chloride in thiazide induced hypokalemia. Kidney Int. 2000;57(2):607–12. doi: 10.1046/j.1523-1755.2000.00881.x.

Unwin RJ, Luft FC, Shirley DG. Pathophysiology and management of hypokalemia: a clinical perspective. Nat Rev Nephrol. 2011;7(2):75–84. doi: 10.1038/nrneph.2010.175.

Zheng T, Wang J, Meng Q, Zhang R, Ma Y, Dong Y, et al. Effect of dynamic stratified potassium supplementation in elderly patients with chronic heart failure and moderate to severe hypokalaemia-a randomised, controlled trial. J Int Med Res. 2021;49(10):3000605211053550. doi: 10.1177/03000605211053550.

Milutinović D, Simin D, Zec D. Risk factor for phlebitis: a questionnaire study of nurses’ perception. Rev Lat Am Enfermagem. 2015;23:677–84. doi: 10.1590/0104-1169.0192.2603.

Pucino F, Danielson BD, Carlson JD, Strommen GL, Walker PR, Beck CL, et al. Patient tolerance to intravenous potassium chloride with and without lidocaine. Drug Intell Clin Pharm. 1988;22(9):676–9. doi: 10.1177/106002808802200904.

Grissinger M. Adding Lidocaine to IV Potassium Infusions Can Cause Safety Problems. P T Peer-Rev J Formul Manag. 2008;33(2):70–5.

Ram P, Goyal A, Lu M, Sloan J, McElhaugh W. Use of Aldosterone Antagonist to Treat Diarrhea and Hypokalemia of Ogilvie’s Syndrome. Case Rep Gastrointest Med. 2016;2016:1207240. doi: 10.1155/2016/1207240.

Published

2024-02-17

How to Cite

1.
Herrera-Añazco P, Rivas-Nieto AC, Chang-Davila D, Lluncor Vasquez J. Therapeutic approaches to potassium disorders. Rev. Cuerpo Med. HNAAA [Internet]. 2024 Feb. 17 [cited 2024 Nov. 22];16(4). Available from: http://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/1924

Issue

Section

Review Article

Categories

Recommended Articles

1 2 > >>