[Clinical Practice Guideline for the treatment of COVID-19 in the Social Security of Peru (EsSalud)]
DOI:
https://doi.org/10.35434/rcmhnaaa.2022.15Supl.%201.1685Keywords:
COVID-19, Clinical Practice Guideline, Evidence-Based Medicine, GRADE Approach, Social Security , PeruAbstract
Introduction: Since the beginning of the COVID-19 pandemic, different drugs and medications have been used for the prevention and treatment of COVID-19 infection. Likewise, various investigations have been carried out to evaluate the efficacy and safety of these interventions, many of which have been shown to generate more harm than benefit for the patient, for this reason it is necessary to standardize the management of adult patients with COVID-19 in our context. Objective: To provide evidence-based clinical recommendations for the management of adults with COVID-19. Methods: A guideline development group (GEG) was formed that included medical specialists and methodologists. For its elaboration, GEG decided to carry out a rapid adaptation of the Guide for the care of critical adult patients with COVID-19 in the Americas of the Pan American Health Organization (PAHO) as well as to carry out searches for novo questions. For the formulation of the recommendations, the evidence frameworks for the decision (EtD) of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology were developed. Results: This CPG addressed 28 clinical questions, divided into three topics: prevention, diagnosis and management. Based on these questions, 33 recommendations (16 strong and 17 conditional), 26 good clinical practices (GCP) and 2 flowcharts were formulated. This CPG was published in its third version in December 2021 Conclusion: This article summarizes the methodology and evidence-based conclusions of the CPG for the management of adults with COVID 19 in EsSalud.
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Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak- A n update on the status. Mil Med Res [Internet]. 2020 Mar 13 [cited 2022 Aug 2];7(1):1–10. Available from: https://bit.ly/3GcgnFm
WHO Coronavirus (COVID-19) Dashboard. WHO Coronavirus (COVID-19) Dashboard With Vaccination Data [Internet]. 2022 [cited 2022 Aug 2]. Available from: https://covid19.who.int/
Johns Hopkins. Mortality Analyses [Internet]. Coronavirus Resource Center; 2022 [cited 2022 Aug 2]. Available from: https://coronavirus.jhu.edu/data/mortality
Data - Covid-19 [Internet]. 2022 [cited 2022 Aug 2]. Available from: https://apps.essalud.gob.pe/data-covid-19/#/
The Lancet Infectious Diseases. The COVID-19 infodemic. The Lancet Infectious Diseases. 2020; 20(8):875. Doi: 10.1016/S1473-3099(20)30565-X
Pafundi PC, Galiero R, Simeon V, Rinaldi L, Perrella A, Vetrano E, et al. Lack of effect on in-hospital mortality of drugs used during COVID-19 pandemic: Findings of the retrospective multicenter COVOCA study. PLoS ONE. 2021;16(9): e0256903. Doi: 10.1371/journal.pone.0256903
Kow CS, Merchant HA, Mustafa ZU, Syed ·, Hasan S. The association between the use of ivermectin and mortality in patients with COVID-19: a meta-analysis. Pharmacological Reports. 2021;3:1473–9. Doi: 10.1007/s43440-021-00245-z
Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, et al. Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19 A Randomized Clinical Trial. JAMA. 2020;324(21):2165–76. Doi: doi: 10.1001/jama.2020.22240.
Ministerio de Salud. Manejo ambulatorio de personas afectadas por la COVID-19 en el Perú [Internet]. Resolución Ministerial N° 947-2020 [Citado 5 agosto del 2022]. Disponible en: https://bit.ly/3O2yek0
Ministerio de Salud. Documento Técnico: Manejo de personas afectadas por COVID-19 en áreas de atención crítica [Internet]. Resolución Ministerial N° 163-2020 [Citado 5 agosto del 2022]. Disponible en: https://bit.ly/3UCfbjc
Organización Panamericana de la Salud 2021. Guía para el cuidado de pacientes adultos críticos con COVID-19 en las Américas. Versión 3, [Internet]. 2021 [cited 2022 Jul 19]. Available from: https://iris.paho.org/handle/10665.2/53894
Pan American Health Organization 2021. Ongoing Living Update of COVID-19 Therapeutic Options: Summary of Evidence. Rapid Review, 14 July 2021. PAHO/IMS/EIH/COVID-19/21-019 [Internet]. 2021 [cited 2021 Jul 19]. Available from: https://bit.ly/3UVkWbt
COVID-19 - all types of questions. Living Overview of the Evidence (L·OVE) [Internet]. 2022 [cited 2022 Aug 1]. Available from: https://bit.ly/3G7uU5k
Andrews JC, Sch€ Unemann HJ, Oxman AD, Pottie K, Meerpohl JJ, Coello PA, et al. GRADE guidelines: 15. Going from evidence to recommendationddeterminants of a recommendation’s direction and strength. JCE. 2013;66:726–35. doi: 10.1016/j.jclinepi.2013.02.003.
Alonso-Coello P, Oxman AD, Moberg J, Brignardello-Petersen R, Akl EA, Davoli M, et al. GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 2: Clinical practice guidelines. BMJ. 2016;353(I2089):1–9. Doi: 10.1136/bmj.i2089
Andrews J, Guyatt G, Oxman AD, Alderson P, Dahm P, Falck-Ytter Y, et al. GRADE SERIES GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations. JCE. 2013;66:719–25. Doi: 10.1016/j.jclinepi.2012.03.013
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Copyright (c) 2022 Samuel Pecho-Silva, José Montes-Alvis, Lesly Karem Chávez-Rimache, Juan José Pareja Ramos, Rosa Luz López Martínez, Gastón Cristóbal Marreros Ascoy, Diego Daniel García Choza, Cherie Quiroz Cortegana, Christian Alexander Chau Ramos, Sergio André Goicochea Lugo, Naysha Becerra-Chauca, Wendy Nieto-Gutierrez, David Garcia-Gomero, Gandy Kerlin Dolores-Maldonado, Alvaro Taype-Rondan, Carolina Delgado-Flores, Stefany Salvador-Salvador, Lourdes Carrera-Acosta
This work is licensed under a Creative Commons Attribution 4.0 International License.
