Hyperglycemia is associated with mortality in pediatric intensive care unit
DOI:
https://doi.org/10.35434/rcmhnaaa.2022.154.1478Keywords:
hyperglycemia, mortality, Intensive Care Units, Pediatric, Critical IllnessAbstract
Objective: To determine the association between glycemia values and mortality in the Pediatric Intensive Care Unit. The study: Retrospective cohort study in pediatric patients between 1 month and 18 years; hospitalized in the PICU for more than 48 hours. Findings: 184 patients were included. The median age was 33.5 months; mortality was 11.54%. The adjusted analysis showed that maximum glucose in 24 hours and PIM2 scale value could be presented as risk factors for mortality, unlike sex, age, and Glasgow scale value, which were presented as protective factors. Conclusion: In the series evaluated, an association was found between the value of maximum glucose in the first 24 hours and mortality in the PICU. Prospective studies are needed to assess this association.
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Faustino EV, Apkon M. Persistent hyperglycaemia in critically ill children. J Pediatrics. 2005; 146:30–34.
Srinivasan V, Spinella PC, Drott HR, Roth CL, Helfaer MA, Nadkarni V. Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatr Crit Care Med. 2004;5(4):329–336.
Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai M. Association of hyperglycemia with increased mortality after severe burn injury. J Trauma. 2001;51(3):540–544.
Prieser JC, Devos P, Van den Berghe G. Tight control of glycaemia in critically ill patients. Curr Opin Nutr Metab Care. 2002; 5:533–537.
Yung M, Wilkins B, Norton L, Slater A, Paediatric Study Group; Australian New Zealand Intensive Care Society Glucose control, organ failure, and mortality in pediatric intensive care. Pediatr Crit Care Med. 2008;9(2):147–152.
Tantaleán J, León R, Santos A, Barrientos A. Hiperglicemia y mortalidad en niños críticamente enfermos. Rev Peru Pediatr. 2006:6-12.
Nayak P, Davies P, Narendran P, Laker S, Gao F, Gough S, et al. Early change in blood glucose concentration is an indicator of mortality in critically ill children. Intensive Care Med. 2013; 39:123–128.
Slater A, Shann F, Pearson G (2003) Paediatric Index of Mortality (PIM) Study Group. PIM2: a revised version of the Paediatric Index of Mortality. Intensive Care Med 29:278 -285.
Patki V, Chougule S. Hyperglycemia in critically ill children. Indian J Crit Care Med.2014;18(1):8-13.
Bae W, Ahn MB. Association between Stress Hyperglycemia and Adverse Outcomes in Children Visiting the Pediatric Emergency Department. Children (Basel). 2022 Apr 2;9(4):505.
Maritim AC, Sanders RA, Watkins JB 3rd. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 2003; 17(1):24–38.
Fattorusso V, Nugnes R, Casertano A, Valerio G, Mozzillo E, Franzese A. Non-Diabetic Hyperglycemia in the Pediatric Age: Why, How, and When to Treat? Curr Diab Rep. 2018 Oct 29;18(12):140
Khan S, Ibrahim M, Anwar-ul-Haq. Frequency and Mortality Associated with Hyperglycemia in Critically Ill Children. J Coll Physicians Surg Pak. 2015 Dec;25(12):878-81.
Cochran A, Scaife ER, Hansen KW, Downey EC. Hyperglycemia and outcomes from pediatric traumatic brain injury. J Trauma. 2003;55(6):1035–1038.
Branco RG, Garcia PC, Piva JP, Casartelli CH, Seibel V, Tasker RC. Glucose level and risk of mortality in pediatric septic shock. Pediatr Crit Care Med. 2005;6(4):470–472.
Preissig CM, Rigby MR. Pediatric critical illness hyperglycemia: risk factors associated with development and severity of hyperglycemia in critically ill children. J Pediatr. 2009;155(5):734–739.
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Copyright (c) 2023 Alejandra Castañeda, Paola Rojas-Vivanco , Alexi Chávez-Valdivia , María del Carmen Valdivia-Tapia, Nilton Yhuri Carreazo
This work is licensed under a Creative Commons Attribution 4.0 International License.
