Lupus Eritematoso Sistémico y Fatiga

Autores/as

  • Claudia Elera-Fitzcarrald Servicio de Reumatología, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú. Escuela Profesional de Medicina Humana, Universidad Privada San Juan Bautista, Ica, Perú.
  • Manuel Ugarte-Gil Servicio de Reumatología. Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú. Facultad de Medicina Universidad Científica del Sur, Lima, Perú

DOI:

https://doi.org/10.35434/rcmhnaaa.2022.153.1665

Palabras clave:

Fatiga, Lupus Eritematoso Sistémico, Calidad de Vida Relacionada a la Salud

Resumen

El Lupus Eritematoso Sistémico (LES) es una enfermedad autoinmune inflamatoria crónica que tiene como uno de sus síntomas más frecuentes la fatiga. La etiología de ésta es multifactorial, existen factores relacionados a la propia enfermedad, estilos de vida, comorbilidades y tratamiento que están asociados. Asimismo, se cuenta con diversos factores para poder medirla, siendo los instrumentos más utilizados: Escala Análoga Visual (EVA), “Krupp Fatigue Severity Scale” (FSS) y el “Functional Assessment of Chronic Illness Therapy Fatigue” (FACIT-Fatigue). El impacto de la fatiga en el paciente con LES es importante ya que repercute en su calidad de vida.

Descargas

Los datos de descargas todavía no están disponibles.

Métricas

Cargando métricas ...

Biografía del autor/a

Claudia Elera-Fitzcarrald, Servicio de Reumatología, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú. Escuela Profesional de Medicina Humana, Universidad Privada San Juan Bautista, Ica, Perú.

1. Médico Reumatólogo

Manuel Ugarte-Gil, Servicio de Reumatología. Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú. Facultad de Medicina Universidad Científica del Sur, Lima, Perú

1. Médico Reumatólogo 

Citas

Tanaka M, Watanabe Y. Supraspinal regulation of physical fatigue. Neurosci Biobehav Rev [Internet]. 2012;36(1):727–34.

Davis MP, Walsh D. Mechanisms of fatigue. J Support Oncol. 2010;8(4):164–74.

Kluger BM, Krupp LB, Enoka RM. Fatigue and fatigability in neurologic illnesses: Proposal for a unified taxonomy. Neurology. 2013;80(4):409–16.

Fava A, Petri M. SLE: Diagnosis and clinical management. Physiol Behav. 2020;176(3):139–48.

Urowitz MB, Gladman DD, Tom BDM, Ibañez D, Farewell VT. Changing patterns in mortality and disease outcomes for patients with systemic lupus erythematosus. J Rheumatol. 2008;35(11):2152–8.

Moses N, Wiggers J, Nicholas C, Cockburn J. Prevalence and correlates of perceived unmet needs of people with systemic lupus erythematosus. Patient Educ Couns. 2005;57(1):30–8.

Ahn GE, Ramsey-Goldman R. Fatigue in systemic lupus erythematosus. Int J Clin Rheumtol. 2012;7(2):217–27.

Cleanthous S, Tyagi M, Isenberg DA, Newman SP. What do we know about self-reported fatigue in systemic lupus erythematosus? Lupus. 2012;21(5):465–76.

Zhu TY, Tam LS, Li EK. Cost-of-illness studies in systemic lupus erythematosus: A systematic review. Arthritis Care Res. 2011;63(5):751–60.

Cornet A, Andersen J, Myllys K, Edwards A, Arnaud L. Living with systemic lupus erythematosus in 2020: A European patient survey. Lupus Sci Med. 2021;8(1).

Finsterer J, Mahjoub SZ. Fatigue in Healthy and Diseased Individuals. Am J Hosp Palliat Med. 2014;31(5):562–75.

Omdal R, Mellgren SI, Koldingsnes W, Jacobsen EA, Husby G. Fatigue in patients with systemic lupus erythematosus: Lack of associations to serum cytokines, antiphospholipid antibodies, or other disease characteristics. J Rheumatol. 2002;29(3):482–6.

Cleanthous S, Strzok S, Haier B, Cano S, Morel T. The Patient Experience of Fatigue in Systemic Lupus Erythematosus: A Conceptual Model. Rheumatol Ther [Internet]. 2022;9(1):95–108.

Katz P. Fatigue in Rheumatoid Arthritis. Curr Rheumatol Rep. 2017;19(5).

Norden DM, Bicer S, Clark Y, Jing R, Henry CJ, Wold LE, et al. Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function. Brain Behav Immun. 2015;43.

Bluthé RM, Beaudu C, Kelley KW, Dantzer R. Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats. Brain Res. 1995;677(1).

Louati K, Berenbaum F. Fatigue in chronic inflammation - a link to pain pathways. Vol. 17, Arthritis Research and Therapy. 2015.

Bergman MJ, Shahouri SS, Shaver TS, Anderson JD, Weidensaul DN, Busch RE, et al. Is fatigue an inflammatory variable in rheumatoid arthritis (RA)? Analyses of fatigue in ra, osteoarthritis, and fibromyalgia. J Rheumatol. 2009;36(12).

Groth Madsen S, Danneskiold-Samsøe B, Stockmarr A, Bartels EM. Correlations between fatigue and disease duration, disease activity, and pain in patients with rheumatoid arthritis: a systematic review. Vol. 45, Scandinavian Journal of Rheumatology. 2016.

Van Steenbergen HW, Tsonaka R, Huizinga TWJ, Boonen A, Van Der Helm-Van Mil AHM. Fatigue in rheumatoid arthritis; A persistent problem: A large longitudinal study. RMD Open. 2015;1(1).

Tench CM, McCurdie I, White PD, D’Cruz DP. The prevalence and associations of fatigue in systemic lupus erythematosus. Rheumatology. 2000;39(11).

Wang B, Gladman DD, Urowitz MB. Fatigue in lupus is not correlated with disease activity. J Rheumatol. 1998;25(5).

Azizoddin DR, Gandhi N, Weinberg S, Sengupta M, Nicassio PM, Jolly M. Fatigue in systemic lupus: the role of disease activity and its correlates. Lupus. 2019;28(2).

Wysenbeek AJ, Leibovici L, Weinberger A, Guedj D. Fatigue in systemic lupus erythematosus. Prevalence and relation to disease expression. Rheumatology. 1993;32(7).

Zonana-Nacach A, Roseman JM, McGwin G, Friedman AW, Baethge BA, Reveille JD, et al. Systemic lupus erythematosus in three ethnic groups. VI: Factors associated with fatigue within 5 years of criteria diagnosis. Lupus. 2000;9(2).

Arnaud L, Gavand PE, Voll R, Schwarting A, Maurier F, Blaison G, et al. Predictors of fatigue and severe fatigue in a large international cohort of patients with systemic lupus erythematosus and a systematic review of the literature. Rheumatol (United Kingdom). 2019;58(6).

Ugarte-Gil MF, Gamboa-Cardenas RV, Reátegui-Sokolova C, Pimentel-Quiroz VR, Medina M, Elera-Fitzcarrald C, et al. Severe flares are associated with a poorer health-related quality of life (HRQoL) in patients with SLE: data from the Almenara Lupus Cohort. Lupus Sci Med. 2022;9(1).

Ugarte-Gil MF, Gamboa-Cárdenas RV, Reátegui-Sokolova C, Medina-Chinchón M, Zevallos F, Elera-Fitzcarrald C, et al. Better Health-Related Quality of Life in Systemic Lupus Erythematosus Predicted by Low Disease Activity State/Remission: Data From the Peruvian Almenara Lupus Cohort. Arthritis Care Res. 2020;72(8).

Emamikia S, Oon S, Gomez A, Lindblom J, Borg A, Enman Y, et al. Impact of remission and low disease activity on health-related quality of life in patients with systemic lupus erythematosus. Rheumatology. 2022;

Guzman J, Cardiel MH, Arce-Salinas A, Sanchez-Guerrero J, Alarcon-Segovia D. Measurement of disease activity in systemic lupus erythematosus. Prospective validation of 3 clinical indices. J Rheumatol. 1992;19(10).

Bae SC, Koh HK, Chang DK, Kim MH, Park JK, Kim SY. Reliability and validity of systemic lupus activity measure-revised (SLAM-R) for measuring clinical disease activity in systemic lupus erythematosus. Lupus. 2001;10(6).

Vitali C, Bencivelli W, Isenberg DA, Smolen JS, Snaith ML, Sciuto M, et al. Disease activity in systemic lupus erythematosus: Report of the Consensus Study Group of the European Workshop for Rheumatology Research. II. Identification of the variables indicative of disease activity and their use in the development of an acticity score. In: Clinical and Experimental Rheumatology. 1992.

Gladman D, Ginzler E, Goldsmith C, Fortin P, Liang M, Urowitz M, et al. The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum. 1996;39(3):363–9.

Isenberg DA, Rahman A, Allen E, Farewell V, Akil M, Bruce IN, et al. BILAG 2004. Development and initial validation of an updated version of the British Isles Lupus Assessment Group’s disease activity index for patients with systemic lupus erythematosus. Rheumatology. 2005;44(7).

Gregg LP, Jain N, Carmody T, Minhajuddin AT, Rush AJ, Trivedi MH, et al. Fatigue in nondialysis chronic kidney disease: Correlates and association with kidney outcomes. Am J Nephrol. 2019;50(1).

Elera-Fitzcarrald C, Alva M, Gamboa-Cardenas R, Mora-Trujillo CS, Zevallos F, García-Poma A, et al. Factors associated with health-related quality of life in Peruvian patients with systemic lupus erythematosus. Lupus. 2018;27(6).

Elera-Fitzcarrald C, Reátegui-Sokolova C, Gamboa-Cárdenas R V., Medina M, Zevallos F, Pimentel-Quiroz VR, et al. Age at diagnosis and health-related quality of life are associated with fatigue in systemic lupus erythematosus patients: Data from the Almenara Lupus Cohort. Lupus. 2020;29(12).

Mancuso CA, Perna M, Sargent AB, Salmon JE. Perceptions and measurements of physical activity in patients with systemic lupus erythematosus. Lupus. 2011;20(3).

Katz P, Gregorich S, Yazdany J, Trupin L, Julian L, Yelin E, et al. Obesity and its measurement in a community-based sample of women with systemic lupus erythematosus. Arthritis Care Res. 2011;63(2).

Petri M. Detection of coronary artery disease and the role of traditional risk factors in the Hopkins Lupus Cohort. Vol. 9, Lupus. 2000.

Chaiamnuay S, Bertoli AM, Fernández M, Apte M, Vilá LM, Reveille JD, et al. The impact of increased body mass index on systemic lupus erythematosus: Data from LUMINA, a multiethnic cohort. J Clin Rheumatol. 2007;13(3).

Chandrasekhara PKS, Jayachandran NV, Rajasekhar L, Thomas J, Narsimulu G. The prevalence and associations of sleep disturbances in patients with systemic lupus erythematosus. Mod Rheumatol. 2009;19(4).

Greenwood KM, Lederman L, Lindner HD. Self-reported sleep in systemic lupus erythematosus. Clin Rheumatol. 2008;27(9).

Ranjbaran Z, Keefer L, Stepanski E, Farhadi A, Keshavarzian A. The relevance of sleep abnormalities to chronic inflammatory conditions. Vol. 56, Inflammation Research. 2007.

Brey RL, Holliday SL, Saklad AR, Navarrete MG, Hermosillo-Romo D, Stallworth CL, et al. Neuropsychiatric syndromes in lupus: Prevalence using standardized definitions. Neurology. 2002;58(8).

Krupp LB, LaRocca NG, Muir J, Steinberg AD. A study of fatigue in systemic lupus erythematosus. J Rheumatol. 1990;17(11).

Omdal R, Waterloo K, Koldingsnes W, Husby G, Mellgren SI. Fatigue in patients with systemic lupus erythematosus: The psychosocial aspects. J Rheumatol. 2003;30(2).

Wang C, Mayo NE, Fortin PR. The relationship between health related quality of life and disease activity and damage in systemic lupus erythematosus. J Rheumatol. 2001;28(3).

Ruiz-irastorza G, Egurbide M V., Olivares N, Martinez-Berriotxoa A, Aguirre C. Vitamin D deficiency in systemic lupus erythematosus: Prevalence, predictors and clinical consequences. Rheumatology. 2008;47(6).

Ruiz-Irastorza G, Gordo S, Olivares N, Egurbide MV, Aguirre C. Changes in vitamin D levels in patients with systemic lupus erythematosus: Effects on fatigue, disease activity, and damage. Arthritis Care Res. 2010;62(8).

Jump RL, Robinson ME, Armstrong AE, Barnes E V., Kilbourn KM, Richards HB. Fatigue in systemic lupus erythematosus: Contributions of disease activity, pain, depression, and perceived social support. J Rheumatol. 2005;32(9).

Iaboni A, Ibanez D, Gladman DD, Urowitz MB, Moldofsky H. Fatigue in systemic lupus erythematosus: Contributions of disordered sleep, sleepiness, and depression. J Rheumatol. 2006;33(12).

Kawka L, Mertz P, Martin T, Arnaud L. Jcm-10-03996-V3.Pdf. 2021;

Hjollund NH, Andersen JH, Bech P. Assessment of fatigue in chronic disease: A bibliographic study of fatigue measurement scales. Vol. 5, Health and Quality of Life Outcomes. 2007.

Barbacki A, Petri M, Avina-Zubieta A, Alarcon GS, Bernatsky S. Fatigue measurements in systemic lupus erythematosus. J Rheumatol. 2019;46(11).

Wewers ME, Lowe NK. A critical review of visual analogue scales in the measurement of clinical phenomena. Res Nurs Health. 1990;13(4).

Cella D, Yount S, Sorensen M, Chartash E, Sengupta N, Grober J. Validation of the Functional Assessment of Chronic Illness Therapy Fatigue Scale relative to other instrumentation in patients with rheumatoid arthritis. J Rheumatol. 2005;32(5).

Yellen SB, Cella DF, Webster K, Blendowski C, Kaplan E. Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. J Pain Symptom Manage. 1997;13(2).

Kosinski M, Gajria K, Fernandes AW, Cella D. Qualitative validation of the FACIT-Fatigue scale in systemic lupus erythematosus. Lupus. 2013;22(5).

Elera-Fitzcarrald C, Rocha J, Burgos PI, Ugarte-Gil MF, Petri M, Alarcón GS. Measures of Fatigue in Patients With Rheumatic Diseases: A Critical Review. Arthritis Care Res. 2020;72(S10).

Elefante E, Tani C, Stagnaro C, Ferro F, Parma A, Carli L, et al. Impact of fatigue on health-related quality of life and illness perception in a monocentric cohort of patients with systemic lupus erythematosus. BMJ Open Sport Exerc Med. 2020;6(1).

Basta F, Margiotta DPE, Vadacca M, Vernuccio A, Mazzuca C, Picchianti Diamanti A, et al. Is fatigue a cause of work disability in Systemic Lupus Erythematosus? Results from a systematic literature review. Eur Rev Med Pharmacol Sci. 2018;22(14).

Reategui-Sokolova C, Gamboa-Cárdenas RV, Medina M, Zevallos-Miranda F, Zeña-Huancas PA, Elera-Fitzcarrald C, et al. Health-Related Quality of Life and fatigue are associated with a higher work productivity impairment in systemic lupus erythematosus patients: Data from the Almenara Lupus Cohort. Lupus. 2021;30(13).

Gordon C, Isenberg D, Lerstrøm K, Norton Y, Nikaï E, Pushparajah DS, et al. The substantial burden of systemic lupus erythematosus on the productivity and careers of patients: A European patient-driven online survey. Rheumatol (United Kingdom). 2013;52(12).

Sterling KL, Gallop K, Swinburn P, Flood E, French A, Sawah S Al, et al. Patient-reported fatigue and its impact on patients with systemic lupus erythematosus. Lupus. 2014;23(2).

Karlson EW, Liang MH, Eaton H, Huang J, Fitzgerald L, Rogers MP, et al. A randomized clinical trial of a psychoeducational intervention to improve outcomes in systemic lupus erythematosus. Arthritis Rheum. 2004;50(6).

Yuen HK, Holthaus K, Kamen DL, Sword DO, Breland HL. Using Wii Fit to reduce fatigue among African American women with systemic lupus erythematosus: A pilot study. Lupus. 2011;20(12).

Hartkamp A, Geenen R, Godaert GLR, Bijl M, Bijlsma JWJ, Derksen RHWM. Effects of dehydroepiandrosterone on fatigue and well-being in women with quiescent systemic lupus erythematosus: A randomised controlled trial. Ann Rheum Dis. 2010;69(6).

Navarra S V., Guzmán RM, Gallacher AE, Hall S, Levy RA, Jimenez RE, et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: A randomised, placebo-controlled, phase 3 trial. Lancet. 2011;377(9767).

Descargas

Publicado

08-10-2022

Cómo citar

1.
Elera-Fitzcarrald C, Ugarte-Gil M. Lupus Eritematoso Sistémico y Fatiga. Rev. Cuerpo Med. HNAAA [Internet]. 8 de octubre de 2022 [citado 21 de noviembre de 2024];15(3):412-7. Disponible en: http://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/1665

Número

Sección

Artículo de Revisión

Categorías