Microgranular variant of acute promyelocytic leukemia: Morphological findings

Authors

  • José Luis Huerto Servicio de Hematología, Hemoterapia y Banco de Sangre, Hospital Nacional Alberto Sabogal Sologuren, Callao, Perú; Universidad Nacional Mayor de San Marcos.
  • Kevin Hernán Rodriguez Servicio de Hematología, Hemoterapia y Banco de Sangre, Hospital Nacional Alberto Sabogal Sologuren, Callao, Perú.

DOI:

https://doi.org/10.35434/rcmhnaaa.2024.171.2345

Keywords:

Acute promyelocytic leukemia, Microgranular variant

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Author Biographies

José Luis Huerto , Servicio de Hematología, Hemoterapia y Banco de Sangre, Hospital Nacional Alberto Sabogal Sologuren, Callao, Perú; Universidad Nacional Mayor de San Marcos.

  1. Médico cirujano, especialidad en patología clínica (médico patólogo clínico)

Kevin Hernán Rodriguez, Servicio de Hematología, Hemoterapia y Banco de Sangre, Hospital Nacional Alberto Sabogal Sologuren, Callao, Perú.

  1. Médico cirujano, especialidad en patología clínica (médico patólogo clínico)

References

Swerdlow SH, International Agency for Research on Cancer. WHO classification of tumours of haematopoietic and lymphoid tissues: Vol. 2: International Agency for Research on Cancer. 2008.

Avvisati G, Lo Coco F, Mandelli F. Acute promyelocytic leukemia: clinical and morphologic features and prognostic factors. Semin Hematol. 2001;38(1):4–12. DOI: 10.1016/s0037-1963(01)90001-0

McDonnell MH, Smith ET Jr, Lipford EH, Gerber JM, Grunwald MR. Microgranular acute promyelocytic leukemia presenting with leukopenia and an unusual immunophenotype. Hematol Oncol Stem Cell Ther. 2017;10(1):35–8. DOI: 10.1016/j.hemonc.2015.12.004

Neame PB, Soamboonsrup P, Leber B, Carter RF, Sunisloe L, Patterson W, et al. Morphology of acute promyelocytic leukemia with cytogenetic or molecular evidence for the diagnosis: characterization of additional microgranular variants. Am J Hematol. 1997;56(3):131–42. DOI: 10.1002/(sici)1096-8652(199711)56:3<131::aid-ajh1>3.0.co;2-z

Tallman MS, Kim HT, Montesinos P, Appelbaum FR, de la Serna J, Bennett JM, et al. Does microgranular variant morphology of acute promyelocytic leukemia independently predict a less favorable outcome compared with classical M3 APL? A joint study of the North American Intergroup and the PETHEMA Group. Blood. 2010;116(25):5650–9. DOI: 10.1182/blood-2010-06-288613

Rovelli A, Biondi A, Cantù Rajnoldi A, Conter V, Giudici G, Jankovic M, et al. Microgranular variant of acute promyelocytic leukemia in children. J Clin Oncol [Internet]. 1992 [citado el 4 de septiembre de 2022];10(9):1413–8. DOI: https://doi.org/10.1200/JCO.1992.10.9.1413

Castro-Mujica M del C, Sullcahuamán-Allende Y. Subtipos moleculares de PML/RARα en pacientes con leucemia promielocítica aguda. Rev Peru Med Exp Salud Publica [Internet]. 2013 [citado el 4 de septiembre de 2022];30(1):37–40. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1726-46342013000100007

Rasekh EO, Elsayed GM, Madney Y, El Gammal MM. Prognostic significance of bcr-1 and bcr-3 isoforms of PML-RARA and FLT3-ITD in patients with acute promyelocytic leukemia. Clin Lymphoma Myeloma Leuk [Internet]. 2020;20(3):156–67. DOI: 10.1016/j.clml.2019.08.006

Published

2024-05-02

How to Cite

1.
Huerto JL, Rodriguez KH. Microgranular variant of acute promyelocytic leukemia: Morphological findings. Rev. Cuerpo Med. HNAAA [Internet]. 2024 May 2 [cited 2024 Nov. 23];17(1). Available from: http://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/2345