Bilinear Acute Monocytic Leukemia/B BCR ABL positive. presentation of a case
DOI:
https://doi.org/10.35434/rcmhnaaa.2023.162.1820Keywords:
Leukemia, B-Cell, Leukemia, Myeloid, Acute, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Monocytic, AcuteAbstract
Background: Leukemias with an ambiguous phenotype are classified as undifferentiated leukemias and mixed phenotypes, these in turn can be divided into bilinear or biphenotypic and are usually associated with a poor prognosis, especially if they are accompanied by aggressive translocations such as the Philadelphia chromosome. Case report: We present the case of an elderly adult patient who presented acute bilinear leukemia with the presence of a population of monoblastic lineage precursors and another, B lymphoid, evaluated by flow cytometry studies, who also presented the BCR-ABL transcript. , detected by real-time PCR studies. The patient had a poor evolution and died 11 days after her diagnosis. Conclusion: Mixed phenotype leukemias have a poor prognosis and require early diagnosis by flow cytometry and molecular biology to provide timely treatment.
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Velasco Puyó, P., & Murillo Sanjuán, L. (2021). Leucemia aguda en pediatría. Pediatria Integral, 25(6), 296–307.
E, L. P., D M, F. C., D, T. W., Lla, B. E., & P, B. A. (2017). World Health Organization Classification of Tumours (page 203). (S. W. health O. classification of tumours Swerdlow, Ed.) (p. 203).
Gil Cortes, C. (2017). Leucemia aguda de fenotipo mixto. Estudio multicéntrico de supervivencia a largo plazo, factores pronósticos y resultados de tratamiento. Universidad Miguel Hernández de Elche. Retrieved from https://dialnet.unirioja.es/servlet/tesis?codigo=135021
Marsán-Suárez V, Díaz-Domínguez G, Triana-Marrero Y. Diagnóstico, clasificación y tratamiento de la leucemia aguda de linaje ambiguo. Revista Cubana de Hematología, Inmunología y Hemoterapia. 2020; 36(3).
Khan M, Siddiqi R, Naqvi K. An update on classification, genetics, and clinical approach to mixed phenotype acute leukemia (MPAL). Annals of Hematology. 2018;97:945-53.
Wang P, Peng X, Dean X, Gao L, Zhang X, Feng Y. Diagnostic challenges in T-cell lymphoblastic lymphoma, early T-cell precursor acute lymphoblastic leukemia or mixed phenotype acute leukemia. Medicine. 2018;97:1-5.
Porwit A, Béné MC. Multiparameter flow cytometry applications in the diagnosis of mixed phenotype acute leukemia. Cytometry Part B: Clinical Cytometry. 2019;96(3):183-94.
Moraveji S, Torabi A, Nahleh Z, Farrag S, Gaur S. Acute leukemia of ambiguous lineage with trisomy 4 as the sole cytogenetic abnormality: A case report and literature review. Leukemia Research Reports. 2014:33-5.
Jia YN, Li Y, Gong XY, Liu KQ, Ye L, Wang HJ, et al. [Clinical Characteristics of Patients with Ph+ Mixed Phenotype Acute Leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. abril de 2019;27(2):354-9.
Cañizalez Jenny Zadis, Rojas de Atencio Alicia, Urdaneta Karelis, Atencio Rojas Raquel, González Richard, Soto Marisol et al. Transcritos del gen BCR-ABL, en pacientes con leucemia Mieloide crónica en venezuela. Saber. 2015 Sep; 27(3): 422-429.
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Copyright (c) 2023 Stalin Tello Vera , Wendy del Carmen Carpio Vásquez , Carlos Tirado Cruz
This work is licensed under a Creative Commons Attribution 4.0 International License.
