Primary gastric choriocarcinoma: an inusual endoscopic finding
DOI:
https://doi.org/10.35434/rcmhnaaa.2023.162.1740Keywords:
Stomach Neoplasms, Choriocarcinoma, Choriocarcinoma, Non-gestationalAbstract
Introduction: Primary gastric choriocarcinoma (PGC) is a rare and highly aggressive neoplasm that represents less than 0.1% of all gastric cancers. This neoplasm is often confused with gastric adenocarcinoma because it shares clinical, epidemiological and histopathological characteristics, so it is important to maintain a high suspicion of this entity. Case of report: A case of a 64-year-old woman who came to the hospital with non-specific gastrointestinal symptoms that arose anemia, fatigue and early fullness is presented. The endoscopic biopsy of the lesion revealed the presence of PGC in clinical stage IV that presented a partial response after 4 cycles of chemotherapy with the EMA/EP regimen (Etoposide 140 mg, Methotrexate 440 mg, Actinomycin D 0.5 mg/ Etoposide 220 mg, cisplatin 110 mg). Conclusion: To emphasize the poor prognosis of extragonadal choriocarcinomas in contrast to gonadal choriocarcinomas, which usually have a better prognosis.
Downloads
Metrics
References
Gurzu S, Copotoiu C, Tugui A, Kwizera C, Szodorai R, Jung I. Primary gastric choriocarcinoma - a rare and aggressive tumor with multilineage differentiation: A case report. World Journal of Clinical Cases [Internet]. 2019 Jul 26 [cited 2022 Aug 11];7(14):1837–43. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692267/
Martins VF, Moreno F, Vizcaíno JR, Santos J. Primary gastric choriocarcinoma: A rare case. International Journal of Surgery Case Reports [Internet]. 2015 [cited 2022 Aug 11];14:44–7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573415/
Stockton L, Green E, Kaur B, De Winton E. Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature. Case Reports in Oncology. 2018 Mar 14;11(1):151–8.
Eom BW, Jung S-Y, Yoon H, Kook M-C, Ryu KW, Lee JH, et al. Gastric choriocarcinoma admixed with an α-fetoprotein-producing adenocarcinoma and separated adenocarcinoma. World Journal of Gastroenterology [Internet]. 2009 [cited 2022 Aug 11];15(40):5106. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768893/
Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol (2010) 203:531–9. doi:10.1016/j.ajog.2010.06.073
Maehira H, Shimizu T, Sonoda H, Mekata E, Yamaguchi T, Miyake T, et al. A rare case of primary choriocarcinoma in the sigmoid colon. World J Gastroenterol (2013) 19:6683–8. doi:10.3748/wjg.v19.i39.6683
May T, Goldstein DP, Berkowitz RS. Current chemotherapeutic management of patients with gestational trophoblastic neoplasia. Chemother Res Pract (2011) 2011:806256. doi:10.1155/2011/806256
Koelzer VH, Steuer K, Gross UC, Zimmermann D, Paasinen-Sohns A, Mertz KD and Cathomas G (2016) Colorectal Choriocarcinoma in a Patient with Probable Lynch Syndrome. Front. Oncol. 6:252. doi: 10.3389/fonc.2016.00252
Kobayashi, A., Hasebe, T., Endo, Y., Sasaki, S., Konishi, M., Sugito, M., … Ochiai, A. (2005). Primary gastric choriocarcinoma: two case reports and a pooled analysis of 53 cases. Gastric Cancer, 8(3), 178–185. doi:10.1007/s10120-005-0332-9
Raghavapuram, R., Veerankutty, F. H., & Anandakumar, M. (2016). Primary Choriocarcinoma of the Stomach. A Case Report and Review of the Literature. Indian Journal of Surgical Oncology, 7(1), 119–123. doi:10.1007/s13193-016-0494-4
Lee, J. H., Lee, J. K., & Kang, D. B. (2019). Primary Gastric Choriocarcinoma Coexisting with Adenocarcinoma. The Korean Journal of Gastroenterology, 73(6), 350. doi:10.4166/kjg.2019.73.6.350
Iñiguez-Ariza, N.M., Cuenca, D., Franco-Granillo, J. et al. Severe thyrotoxicosis as initial presentation of gastric choriocarcinoma: a case report. J Med Case Reports 16, 159 (2022). https://doi.org/10.1186/s13256-022-03343-5
Shastri A, Daver NG, Hayes TG. Primary gastric chorioadenocarcinoma: a needle in a haystack. Rare Tumors. 2011 Apr 4;3(2):e19. doi: 10.4081/rt.2011.e19. PMID: 21769318; PMCID: PMC3132123.
Yiqin Xiong (MD, PhD), Michelle X. Yang (MD, PhD). Primary gastric choriocarcinoma with multiple metastases – A case report and literature review of carcinogenesis. Human Pathology: case reports. https://doi.org/10.1016/j.ehpc.2019.200330
Zhi Liu, MD, PhD; Jose L. Mira, MD; Jose C. Cruz-Caudillo, MD. Primary Gastric Choriocarcinoma. A Case Report and Review of the Literature. Arch Pathol Lab Med. 2001; 125:1601–1604)
Takahashi K, Tsukamoto S, Saito K, Ohkohchi N, Hirayama K. Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma. World J Gastroenterol. 2013 Aug 21;19(31):5187-94. doi: 10.3748/wjg.v19.i31.5187. PMID: 23964157; PMCID: PMC3746395.
Noguchi, T., Takeno, S., Sato, T. et al. A patient with primary gastric choriocarcinoma who received a correct preoperative diagnosis and achieved prolonged survival. Gastric Cancer 5, 112–117 (2002). https://doi.org/10.1007/s101200200019
Baraka BA, Al Kharusi SS, Al Bahrani BJ, Bhathagar G. Primary Gastric Chorioadenocarcinoma. Oman Med J. 2016 Sep;31(5):381-3. doi: 10.5001/omj.2016.75. PMID: 27602194; PMCID: PMC4996952.
Xiong, Y., & Yang, M. X. (2019). Primary gastric choriocarcinoma with multiple metastases – A case report and literature review of carcinogenesis. Human Pathology: Case Reports, 18, 200330. doi:10.1016/j.ehpc.2019.200330
Stang, A., Trabert, B., Wentzensen, N., Cook, M. B., Rusner, C., Oosterhuis, J. W., & McGlynn, K. A. (2012). Gonadal and extragonadal germ cell tumours in the United States, 1973-2007. International Journal of Andrology, 35(4), 616–625. doi:10.1111/j.1365-2605.2011.01245.x
Downloads
Published
How to Cite
License
Copyright (c) 2023 Joseph Alburqueque-Melgarejo, Brady Beltrán Gárate, Eugenio Américo Palomino Portilla , María del Pilar Quiñones Ávila, Hellen Mariluz Reina Trejo
This work is licensed under a Creative Commons Attribution 4.0 International License.
