Bilateral metabolic lesions in the basal ganglia: Case series and Literature review
DOI:
https://doi.org/10.35434/rcmhnaaa.2023.161.1658Keywords:
Basal ganglia, Neuroimaging, Magnetic Resonance Imaging, TomographyAbstract
Introduction: Basal nuclei are gray matter substances, involved in the regulation of different metabolic functions and are vulnerable to situations of hypoxia and different pathological situations. Imaging findings are not specific in most cases. Case of report: The cases of ten patients with bilateral metabolic lesions in the basal nuclei treated at a national reference hospital in Peru are reported, and a review of the literature is carried out: 3 cases of postoperative hypoparathyroidism, 2 of Wernicke's encephalopathy, 1 with hepatolenticular degeneration, 1 with extrapontine myelinolysis, 1 methanol intoxication and 2 with hypoxic-ischemic encephalopathy. Conclusion: Bilateral lesions of the basal nuclei as a result of metabolic lesions are nonspecific, so the clinical context is of vital importance, as well as the particularities of the imaging findings, for the adequate recognition of the etiological entities and their timely management.
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Van Cauter S, Severino M, Ammendola R, Van Berkel B, Vavro H, van den Hauwe L, et al. Bilateral lesions of the basal ganglia and thalami (central grey matter)—pictorial review. Neuroradiology. 2020;62(12):1565-605.
Tambasco N, Romoli M, Calabresi P. Selective basal ganglia vulnerability to energy deprivation: Experimental and clinical evidences. Progress in Neurobiology. 2018;169:55-75.
Bekiesinska-Figatowska M, Mierzewska H, Jurkiewicz E. Basal ganglia lesions in children and adults. European Journal of Radiology.2013;82(5):837-49.
Latt N, Dore G. Thiamine in the treatment of Wernicke encephalopathy in patients with alcohol use disorders. Internal Medicine Journal. 2014;44(9):911-5.
Chandrakumar A, Bhardwaj A, Jong GW ‘t. Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. Journal of Basic and Clinical Physiology and Pharmacology.2019;30(2):153-62.
Sechi G, Serra A. Wernicke’s encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol. 2007;6(5):442–55.
Ota Y, Capizzano AA, Moritani T, Naganawa S, Kurokawa R, Srinivasan A. Comprehensive review of Wernicke encephalopathy: pathophysiology, clinical symptoms and imaging findings. Jpn J Radiol. 2020;38(9):809-820.
Galvin R, Brathen G, Ivashynka A, Hillbom M, Tanasescu R, Leone MA. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur Journal Neurol. 2010;17:1408-18.
Santos C, Tavares L, Morais M, Marques-Dias MJ, Pezzi LA,Scarabotolo G, et al. Non-alcoholic Wernicke’s encephalopathy: broadening the clinicoradiological spectrum. Br J Radiol.2010;83:437-46.
Zuccoli G, Pipitone N. Neuroimaging findings in acute Wernicke’s encephalopathy: review of the literature. Am J Roentgenol. 2009;192:501-8.
Kakava K, Tournis S, Papadakis G, Karelas I, Stampouloglou P, Kassi E, et al. Postsurgical Hypoparathyroidism: A Systematic Review. In Vivo. 2016;30(3):171-9.
Posen S. Computerized tomography of the brain in surgical hypoparathyroidism. Ann Intern Med. 1979;91(3):415.
Modi S, Tripathi M, Saha S, Goswami R. Seizures in patients with idiopathic hypoparathyroidism: effect of antiepileptic drug withdrawal on recurrence of seizures and serum calcium control. Eur J Endocrinol. 2014;170(5):777‐783.
Brown WD. Osmotic demyelination disorders: central pontine and extrapontine myelinolysis. Curr Opin Neurol 2000; 13: 691–697.
Singh TD, Fugate JE, Rabinstein AA. Central pontine and extrapontine myelinolysis: a systematic review. Eur J Neurol. 2014 Dec;21(12):1443-50.
Ropper AH, Samuels MA. Editores: Adams and Victors. The Acquired Metabolic Disorders of the Nervous System. Principles of Neurology. Ninth edition. Boston: McGraw-Hill Companies, Inc: 2009.
DeLuca GC, Nagy ZS, Esiri MM, Davey P. Evidence for a role for apoptosis in central pontine myelinolysis, Acta Neuropathol 2002; 103: 590-8.
Kallakatta RN, Radhakrishnan A, Fayaz RK,Unnikrishnan JP, Kesavadas C, Sarma SP. Clinical and functional outcome and factors predicting prognosis in osmotic demyelination syndrome (central pontine and/or extrapontine myelinolysis) in 25 patients. J Neurol Neurosurg Psychiatry 2011; 82: 326–331.
Graff-Radford J, Fugate JE, Kaufmann TJ, Mandrekar JN, Rabinstein AA. Clinical and Radiologic Correlations of Central Pontine Myelinolysis Syndrome. Mayo Clinic Proceedings. 2011;86(11):1063-7.
Victor M, Adams RD, Cole M. The acquired (Non-Wilsonian) type of chronic hepatocerebral degeneration. Medicine. 1965;44(5):345-96.
Schwendimann RN, Minagar A. Liver Disease and Neurology. CONTINUUM: Lifelong Learning in Neurology. 2017 Jun;23(3):762.
Shin HW, Park HK. Recent Updates on Acquired Hepatocerebral Degeneration. Tremor and Other Hyperkinetic Movements. 2017 Sep 5;7(0):463.
Sinha S, Taly AB, Ravishankar S, Prashanth LK, Venugopal KS, Arunodaya GR, et al. Wilson’s disease: cranial MRI observations and clinical correlation. Neuroradiology. 2006 Sep 1;48(9):613–21.
Bandmann O, Weiss KH, Kaler SG. Wilson’s disease and other neurological copper disorders. The Lancet Neurology. 2015;14(1):103-13.
Rubinstein D, Escott E, Kelly JP. Methanol intoxication with putaminal and white matter necrosis: MR and CT findings. American Journal of Neuroradiology. 1995;16(7):1492–4.
Blanco M, Casado R, Vázquez F, Pumar JM. CT and MR Imaging Findings in Methanol Intoxication. American Journal of Neuroradiology. 2006 1;27(2):452–4.
Fugate JE. Anoxic-Ischemic Brain Injury. Neurologic Clinics. 2017;35(4):601–11.
Kjos B, Brant-Zawadzki M, Young R. Early CT findings of global central nervous system hypoperfusion. American Journal of Roentgenology. 1983 ;141(6):1227–32.
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