Efecto de la quimiorradiación preoperatoria en estadiaje ganglionar y sobrevida en cáncer de recto: revisión sistemática y metaanálisis

Cristina Alejandra  Armas-Maldonado; Edgar Fermín Yan-Quiroz

doi:10.35434/rcmhnaaa.2022.15Supl. 1.1589

Authors

Cristina Alejandra Armas-Maldonado Facultad de Medicina, Universidad Privada Antenor Orrego, La Libertad, Perú
Edgar Fermín Yan-Quiroz Facultad de Medicina, Universidad Privada Antenor Orrego, La Libertad, Perú. Hospital Alta Complejidad Virgen de la Puerta, Essalud, La Libertad, Perú.

DOI:

https://doi.org/10.35434/rcmhnaaa.2022.15Supl.%201.1589

Keywords:

rectal cancer, Preschool, preoperative radiotherapy, preoperative chemotherapy, lymph nodes

Abstract

OBJECTIVES: To assess the efficacy of surgical resection of more than 12 lymph nodes versus fewer than 12 lymph nodes in patients with rectal cancer after neoadjuvant treatment with chemoradiation. MATERIALS AND METHODS: We conducted a search in Pubmed, Scopus, Web of Science, EMBASE, selecting randomized clinical trials and prospective cohort studies that compared the number of LNs in rectal cancer resected after neoadjuvant treatment. Two independent researchers reviewed and selected the studies that underwent the risk of bias assessment using the NOS tool, finally, the random effects model and the inverse variance method were executed. RESULTS: A total of 3964 articles were reviewed, of which 10 articles were included in the systematic review. The study showed that a lymph node harvest of less than 12 nodes (NL<12) is not related to lower overall survival compared to a finding of more than 12 nodes (NL>12) (HR 0.75; CI 95% 0.52-1.07; p=0.09 ; I2=63%) nor in disease-free survival (HR 0.69; 95% CI 0.36-1.33; p=0.21; I2=92%;). Regarding recurrence (RR 1.46; 95% CI 0.80-2.68; p=0.11; I2=1%;) no relationship was found when comparing both groups either. CONCLUSIONS: The present systematic review showed that there is no relationship between a finding of less than 12 lymph nodes in a lower overall survival nor to a lower disease-free survival when compared with a finding of more than 12 nodes.

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Author Biographies

Cristina Alejandra Armas-Maldonado, Facultad de Medicina, Universidad Privada Antenor Orrego, La Libertad, Perú

1. Bachiller de Medicina

Edgar Fermín Yan-Quiroz, Facultad de Medicina, Universidad Privada Antenor Orrego, La Libertad, Perú. Hospital Alta Complejidad Virgen de la Puerta, Essalud, La Libertad, Perú.

1. Bachiller de Medicina

2. Médico especialista en Cirugía Oncológica

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