Suplemento con vitamina K para el control metabólico en pacientes con Diabetes Mellitus tipo 2. Revisión Sistemática

Kathleen Condemarin Torres; Victor Hugo Bardales Zuta

doi:10.35434/rcmhnaaa.2022.15Supl. 1.1522

Authors

Kathleen Condemarin Torres Universidad Privada Antenor Orrego, Trujillo, Perú.
Victor Hugo Bardales Zuta Universidad Privada Antenor Orrego, Trujillo, Perú

DOI:

https://doi.org/10.35434/rcmhnaaa.2022.15Supl.%201.1522

Keywords:

Type 2 diabetes, Vitamin K, Metabolic control, FBS, Lipid profile

Abstract

Objectives: To determine the effect of vitamin K supplementation on metabolic control in patients with type 2 diabetes mellitus. Materials and methods: Systematic review of randomised controlled trials (RCTs) in five databases. Two authors independently selected studies and extracted information. Risk of bias was performed using the Cochrane collaboration tool. Primary outcomes were need for fasting blood sugar (FBS), total choresterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL). We used mean difference (MD) to assess the effect on continuous outcomes. We used random-effect model. Results: We included two RCTs (n=100). Vitamin K lowers FPS but it wasn't significant (MD -14.58; IC95% -35.95 to 6.78; p=0.18) in comparison with placebo group. Vitamin K supplement has no significant effect in cholesterol total (MD -1.22; IC95% -21.02 to 18.57; p=0.90), HDL (MD -3.61; IC95% -18.44 to 11.22; p=0.63) and LDL (MD -0.69; IC95% -5.81 to 4.43; p=0.79) levels compared with placebo group. Conclusions: Vitamin K supplement has no effect on metabolic control on patients diagnosed with type 2 diabetes.

Key words: Type 2 diabetes; vitamin K; metabolic control; FBS; lipid profile (Source: MeSH-NLM).

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Author Biographies

Kathleen Condemarin Torres, Universidad Privada Antenor Orrego, Trujillo, Perú.

1. Estudiante de medicina

Victor Hugo Bardales Zuta, Universidad Privada Antenor Orrego, Trujillo, Perú

1. Médico cirujano

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