Adverse neonatal outcomes according to degrees of pre-gestational obesity in a public hospital in southern Peru, 2010 to 2019
DOI:
https://doi.org/10.35434/rcmhnaaa.2022.153.1332Keywords:
Maternal obesity, morbid obesity, fetal macrosomia, birth weight , Obesidade, PeruAbstract
Introduction: Maternal obesity, a growing global public health problem, is related to neonatal morbidity and mortality. The objective was to determine adverse neonatal outcomes according to degrees of pregestational obesity. Material and method: Analytical study, retrospective cohort, in pregnant women with a single pregnancy, delivery attended at the Hipolito Unanue hospital in Tacna, Peru, during 2010 to 2019, with live newborns, the cases were 5935 mothers with pre-pregnancy body mass index from 30 Kg/m2 to more, grouped in grade I (BMI 30-34.9 Kg/m2), II (BMI 35-39.9 Kg/m2) and III (BMI>40 Kg/m2), the control mothers with a BMI of 18-24.9 Kg/m2. Pregnant women with diabetes mellitus, preeclampsia, eclampsia and congenital anomalies were excluded. Crude Relative Risk (RR) was used, adjusted for maternal age, schooling and parity, with a 95% confidence interval. Results: The frequency of pre-pregnancy obesity was 14.3% grade I, 3.8% grade II and 1% grade III. The associated neonatal outcomes were: birth weight >4000 grams, for grade I obesity (RRa: 1.9; 95% CI: 1.7-2.0), grade II (RRa: 2.0; 95% CI: 1.8-2.3) and grade III (RRa: 2.1; CI95%: 1.7-2.5); large for gestational age for grade I (RRa: 1.6; 95% CI: 1.4-1.7), grade II (RRa: 1.7; 95% CI: 1.6-1.9) and grade III (RRa: 1.8; CI95%: 1.4-2.1). Conclusions: There is an increased risk of fetal macrosomia and large for gestational age with a higher degree of maternal pregestational obesity
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Farías Marcelo. Obesidad materna: severo problema de salud pública en Chile. Rev Chil Obstet Ginecol. 2013; 78(6): 409-412.
World Health Organization. Diet, nutrition and the prevention of chronic diseases [Internet]. Geneva: Report of a Joint WHO/FAO Expert Consultation; 2002 [citado el 30 de octubre de 2020]. Disponible en: https://bit.ly/2N5qHUu.
The American College of Obstetricians and Gynecologists. Practice Bulletin N° 156: Obesity in pregnancy. Correction. Obstet Gynecol. 2016;128(6):1450. DOI: 10.1097/AOG.0000000000001807.
Jaacks LM, Vandevijvere S, Pan A, McGowan CJ, Wallace C, Imamura F, et al. The obesity transition: stages of the global epidemic. Lancet Diabetes Endocrinol. 2019; 7(3):231-240. DOI: 10.1016/S2213-8587(19)30026-9.
NCD Risk Factor Collaboration. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet. 2016; 387(10026): 1377-1396. DOI: 10.1016/S0140-6736(16)30054-X.
Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014; 384(9945): 766-781. DOI: 10.1016/S0140-6736(14)60460-8.
Godfrey KM, Reynolds RM, Prescott SL, Nyirenda M, Jaddoe VW, Eriksson JG, et al. Influence of maternal obesity on the long-term health of offspring. Lancet Diabetes Endocrinol. 2017; 5(1): 53-64. DOI: 10.1016/S2213-8587(16)30107-3.
World Health Organization. Consideration of the evidence on childhood obesity for the Commission on Ending Childhood Obesity [Internet]. Geneva: Report of the ad hoc working group on science and evidence for ending childhood obesity; 2016 [citado el 26 de noviembre de 2021]. Disponible en: https://bit.ly/3DEACtF.
Catalano PM. Obesity and pregnancy the propagation of a viscous cycle?. J Clin Endocrinol Metab. 2003; 88(8):3505-6. DOI: 10.1210/jc.2003-031046.
Instituto Nacional de Estadística e Informática. Perú Encuesta demográfica y de salud familiar – ENDES Continua, 2010 [Internet]. Lima: Dirección Técnica de Demografía e Indicadores Sociales, INEI; 2011 [citado el 14 de enero de 2022]. Disponible en: https://bit.ly/3DmK186
Instituto Nacional de Estadística e Informática. Perú Encuesta demográfica y de salud familiar – ENDES Continua, 2020 [Internet]. Lima: Dirección Nacional de Censos y Encuestas, INEI; 2021 [citado el 21 de enero de 2022]. Disponible en: https://bit.ly/3gPV55I.
Vigilancia del Sistema de Información del Estado Nutricional en Establecimientos de Salud [Internet]. Instituto Nacional de Salud. Indicadores gestantes enero a diciembre 2019. 2020 [citado 10 de enero de 2022]. Disponible en: https://bit.ly/2LyVOXn.
D’Souza R, Horyn I, Pavalagantharajah S, Zaffar N, Jacob CE. Maternal body mass index and pregnancy outcomes: a systematic review and metaanalysis. Am J Obstet Gynecol MFM. 2019; 1(4):100041. DOI: 10.1016/j.ajogmf.2019.100041.
Ticona-Rendón M, Huanco-Apaza D. Curva de referencia peruana del peso de nacimiento para la edad gestacional y su aplicación para la identificación de una nueva población neonatal de alto riesgo. Rev Peru Med Exp Salud Publica [Internet]. 2007 [cited 2021 Oct 27]; 24(4):325-35. Disponible en: https://bit.ly/3SKVTWO.
Ratnasiri AWG, Lee HC, Lakshminrusimha S, Parry SS, Arief VN, DeLacy IH, et al. Trends in maternal prepregnancy body mass index (BMI) and its association with birth and maternal outcomes in California, 2007–2016: A retrospective cohort study. Plos One. 2019; 14(9): e0222458. DOI: 10.1371/journal.pone.0222458.
Crane J, White J, Murphy P, Burrage L, Hutchens D. The effect of gestational weight gains by body mass index on maternal and neonatal outcomes. J Obstet Gynaecol Can. 2009; 31(1):28-35. DOI: 10.1016/s1701-2163(16)34050-6.
Alves P, Malheiro M, Cavaco Gomes J, Ferraz T, Montenegro N. Risks of maternal obesity in pregnancy: A case-control study in a Portuguese Obstetrical Population. Rev Bras Ginecol Obstet. 2020; 41(12):682–687.
Neumann K, Indorf I, Härtel C, Cirkel C, Rody A, Beyer DA. C-Section Prevalence Among Obese Mothers and Neonatal Hypoglycemia: a Cohort Analysis of the Department of Gynecology and Obstetrics of the University of Lübeck. Geburtshilfe Frauenheilkd. 2017; 77(5):487-494. DOI: 10.1055/s-0043-108763
MacInnis N, Woolcott CG, McDonald S, Kuhle S. Population Attributable Risk Fractions of Maternal Overweight and Obesity for Adverse Perinatal Outcomes. Sci Rep. 2016; 6:22895. DOI: 10.1038/srep22895.
Cheney K, Farber R, Barratt AL, McGeechan K, de Vries B, Ogle R, Black KI. Population attributable fractions of perinatal outcomes for nulliparous women associated with overweight and obesity, 1990-2014. Med J Aust. 2018; 208(3):119-125. DOI: 10.5694/mja17.00344.
Magann E, Doherty D, Sandlin A, Chauhan S, Morrison J. The effects of an increasing gradient of maternal obesity on pregnancy outcomes. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2013; 53(3):250-257. doi: 10.1111/ajo.12047.
Rodríguez C, Álvarez E, Rodríguez R, Pérez M, Alves M. Morbid obesity and fetal-maternal outcomes. Ginecología y Obstetricia de México. 2019; 87(10):647-659. Doi: 10.24245/gom.v87i10.3182.
Catalano PM, McIntyre HD, Cruickshank JK, McCance DR, Dyer AR, Metzger BE, et al. The hyperglycemia and adverse pregnancy outcome study: associations of GDM and obesity with pregnancy outcomes. Diabetes Care. 2012; 35(4):780-6. doi: 10.2337/dc11-1790.
Harmon KA, Gerard L, Jensen DR, Kealey EH, Hernandez TL, Reece MS, et al. Continuous glucose profiles in obese and normal-weight pregnant women on a controlled diet: metabolic determinants of fetal growth. Diabetes Care. 2011; 34(10):2198-204. doi: 10.2337/dc11-0723.
Shapiro AL, Schmiege SJ, Brinton JT, Glueck D, Crume TL, Friedman JE, et al. Testing the fuel-mediated hypothesis: maternal insulin resistance and glucose mediate the association between maternal and neonatal adiposity, the Healthy Start study. Diabetologia. 2015; 58(5):937-41. doi: 10.1007/s00125-015-3505-z
Jansson T, Powell TL. Placental amino acid transporters. En: Moffett A, Barker DJP, Burton GJ, Thornburg K (editors). The Placenta and Human Developmental Programming. Cambridge: Cambridge University Press. 2010:147–160.
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Copyright (c) 2022 Manuel Ticona Rendón, Diana Huanco Apaza, Madelein Claros Euscate
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