Índice Neutrófilo-Linfocito y desenlaces de supervivencia en cáncer testicular : Revisión sistemática y meta analisis
DOI:
https://doi.org/10.35434/rcmhnaaa.2024.171.2048Palabras clave:
Cancer testicular, Indice Neutrófilo-Linfocito (INL) , Supervivencia general, Supervivencia libre de progresiónResumen
Introducción : El cáncer testicular es la neoplasia maligna sólida más común en pacientes jóvenes entre 15 y 44 años , con tendencia al alza durante la última década. Objetivo : Evaluar los valores del índice Neutrófilo-Linfocito (INL) en la supervivencia de pacientes diagnosticados con cáncer testicular. Materiales y Métodos : Metanálisis de modelo de efectos aleatorios evaluando la supervivencia general y la supervivencia libre de progresión , cumpliendo 6 estudios con los criterios de inclusión. Resultados : Se incluyeron 6 estudios , de los cuales se obtuvo una población total de 1315 . Se evaluó los niveles altos del INL , los cuales se asociaron a una menor supervivencia general (HR: 1.75;IC del 95%: 1,04 - 2,92, I2 : 65%). Conclusión : Se encontró asociación entre niveles elevados de INL y menor supervivencia general , a pesar de esto se determinó que este resultado presenta sesgo de publicación, presentando falta de asociación en este resultado.
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Ilktac A, Dogan B, Ersoz C, Akcay M, Akbulut H. The relationship of neutrophil to lymphocyte ratio with testicular cancer. International braz j urol : official journal of the Brazilian Society of Urology. 2020;46(1):101-7. doi: 10.1590/S1677-5538.IBJU.2019.0321
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, et al. Testicular cancer. Nature Reviews Disease Primers 2018 4:1. 2018;4(1):1-24. Available at : https://www.nature.com/articles/s41572-018-0029-0
Huang J, Chan SC, Tin MS, Liu X, Lok VT, Ngai CH, et al. Worldwide Distribution, Risk Factors, and Temporal Trends of Testicular Cancer Incidence and Mortality: A Global Analysis. Eur Urol Oncol. 2022;5(5):566-76. doi: https://doi.org/10.1016/j.euo.2022.06.009
Smith ZL, Werntz RP, Eggener SE. Testicular Cancer: Epidemiology, Diagnosis, and Management. Medical Clinics of North America. 2018;102(2):251-64. doi : 10.1016/j.mcna.2017.10.003
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA: A Cancer Journal for Clinicians. 2021;71(1):7-33. doi : 10.3322/caac.21654
Testicular Cancer: Statistics | Cancer.Net. Available at : https://www.cancer.net/cancer-types/testicular-cancer/statistics#:~:text=About%201%20out%20of%20every,ages%20of%2020%20and%2034.
Alban ATZ, Alban ATZ, Flores ECB, Vélez AEI, Quiroga AGB. Tratamiento y pronóstico de cáncer testicular. RECIMUNDO. 2020;4(4):445-53. doi : 10.26820/recimundo/4.(4).octubre.2020.445-453
Multhoff G, Molls M, Radons J. Chronic inflammation in cancer development. Frontiers in Immunology. 2012;2(JAN):98-. doi : 10.3389/fimmu.2011.00098
Coussens LM, Werb Z. Inflammation and cancer. Nature 2002 420:6917. 2002;420(6917):860-7. Available at : https://www.nature.com/articles/nature01322
Grivennikov SI, Greten FR, Karin M. Immunity, Inflammation, and Cancer. Cell. 2010;140(6):883-99. doi : 10.1016/j.cell.2010.01.025
Cupp MA, Cariolou M, Tzoulaki I, Aune D, Evangelou E, Berlanga-Taylor AJ. Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies. BMC medicine. 2020;18(1). doi : 10.1186/s12916-020-01817-1
Templeton AJ, McNamara MG, Šeruga B, Vera-Badillo FE, Aneja P, Ocaña A, et al. Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis. JNCI: Journal of the National Cancer Institute. 2014;106(6). doi : 10.1093/jnci/dju124
Tang L, Li X, Wang B, Luo G, Gu L, Chen L, et al. Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Localized and Advanced Prostate Cancer: A Systematic Review and Meta-Analysis. PloS one. 2016;11(4). doi : 10.1371/journal.pone.0153981
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700. doi : 10.1136/bmj.b2700
McGowan J, Sampson M, Salzwedel DM, Cogo E, Foerster V, Lefebvre C. PRESS Peer Review of Electronic Search Strategies: 2015 Guideline Statement. J Clin Epidemiol. 2016;75:40-6. doi : 10.1016/j.jclinepi.2016.01.021
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app forsystematic reviews. Systematic Reviews. 2016;5(1):1-10. Available at : Elmagarmid A. Rayyan—a web and mobile app forsystematic reviews. Systematic Reviews.
Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2021. Available at : https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
Fankhauser CD, Sander S, Roth L, Gross O, Eberli D, Sulser T, et al. Systemic inflammatory markers have independent prognostic value in patients with metastatic testicular germ cell tumours undergoing first-line chemotherapy. Br J Cancer. 2018;118(6):825-30. Available at : 10.1038/bjc.2017.467
Göger YE, Özkent MS, Karaağaç M, Uçmak H, Artaç M. Prognostic Value of Systemic Immune-Inflammation Index in Patients with Testicular Cancer: A Retrospective CaseControl Study. Bull Urooncol. 2021;20(4):252-7. doi : 10.4274/uob.galenos.2021.2021.3.2
Yoshinaga K, Sadahira T, Maruyama Y, Mitsui Y, Iwata T, Wada K, et al. Comparison of inflammation-based prognostic scores as predictors of survival outcomes in patients with germ cell tumors. Investig Clin Urol. 2021;62(1):47-55. Available at : 10.4111/icu.20200103
Herraiz-Raya L, Moreillo-Vicente L, Martínez-Ruiz J, Agustí-Martínez A, Fernández-Anguita PJ, Esper-Rueda JA, et al. Valor pronóstico del recuento de leucocitos y plaquetas, en tumores testiculares de células germinales. Actas Urológicas Españolas. 2019;43(6):284-92. Available at : 10.1016/j.acuro.2019.02.002
Ribnikar D, Stukalin I, Bedard PL, Hamilton RJ, Jewett M, Warde P, et al. The Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Metastatic Testicular Cancer. Current oncology (Toronto, Ont). 2020;28(1):107-14. doi : 10.3390/curroncol28010014
Yang J, Guo X, Hao J, Dong Y, Zhang T, Ma X. The Prognostic Value of Blood-Based Biomarkers in Patients With Testicular Diffuse Large B-Cell Lymphoma. Front Oncol. 2019;9:1392. doi : 10.3389/fonc.2019.01392
Volcic M, Karl S, Baumann B, Salles D, Daniel P, Fulda S, et al. NF-κB regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexes. Nucleic Acids Research. 2012;40(1):181-.. doi : 10.1093/nar/gkr687
Taniguchi K, Karin M. NF-κB, inflammation, immunity and cancer: coming of age. Nature reviews Immunology. 2018;18(5):309-24. doi : 10.1038/nri.2017.142
Adam JK, Odhav B, Bhoola KD. Immune responses in cancer. Pharmacology & therapeutics. 2003;99(1):113-32. doi : 10.1016/s0163-7258(03)00056-1
Chen G, Zhu L, Yang Y, Long Y, Li X, Wang Y. Prognostic Role of Neutrophil to Lymphocyte Ratio in Ovarian Cancer: A Meta-Analysis. Technology in Cancer Research & Treatment. 2018;17. doi : 10.1177/1533033818791500
Mjaess G, Chebel R, Karam A, Moussa I, Pretot D, Abi Tayeh G, et al. Prognostic role of neutrophil-to-lymphocyte ratio (NLR) in urological tumors: an umbrella review of evidence from systematic reviews and meta-analyses. Acta Oncologica. 2021;60(6):704-13. doi : 10.1080/0284186X.2021.1886323
Naszai M, Kurjan A, Maughan TS. The prognostic utility of pre‐treatment neutrophil‐to‐lymphocyte‐ratio (NLR) in colorectal cancer: A systematic review and meta‐analysis. Cancer Medicine. 2021;10(17):5983-97. doi : 10.1002/cam4.4143
Zheng J, Cai J, Li H, Zeng K, He L, Fu H, et al. Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio as Prognostic Predictors for Hepatocellular Carcinoma Patients with Various Treatments: a Meta-Analysis and Systematic Review. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017;44(3):967-81. doi : 10.1159/000485396
Ghoshal A, Garmo H, Arthur R, Hammar N, Jungner I, Malmström H, et al. Serum biomarkers to predict risk of testicular and penile cancer in AMORIS. Ecancermedicalscience. 2017;11. doi : 10.3332/ecancer.2017.762
Saito K, Kihara K. C-reactive protein as a biomarker for urological cancers. Nature reviews Urology. 2011;8(12):659-66. doi : 10.1038/nrurol.2011.145
Olcucu MT, Karamik K, Yilmaz K, Okuducu Y, Cakir S, Ates M. Preoperative Inflammation Markers and De Ritis Ratio in Predicting Clinical Presentation and Prognosis of Patients with Testicular Germ Cell Tumors. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2020;30(10):1041-6. doi : Preoperative Inflammation Markers and De Ritis Ratio in Predicting Clinical Presentation and Prognosis of Patients with Testicular Germ Cell Tumors.
Salazar-Valdivia FE, Valdez-Cornejo VA, Ulloque-Badaracco JR, Hernandez-Bustamante EA, Alarcón-Braga EA, Mosquera-Rojas MD, et al. Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis. Diagnostics. 2023;13(5):843. doi : 10.3390/diagnostics13050843
Zahorec R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5-14. Available at : https://pubmed.ncbi.nlm.nih.gov/11723675/
Eun S, Ho IG, Bae GE, Kim H, Koo CM, Kim MK, et al. Neutrophil-to-lymphocyte ratio for the diagnosis of pediatric acute appendicitis: a systematic review and meta-analysis. European review for medical and pharmacological sciences. 2021;25(22):7097-107. doi : 10.26355/eurrev_202111_27263
Ulloque-Badaracco JR, Ivan Salas-Tello W, Al-kassab-Córdova A, Alarcón-Braga EA, Benites-Zapata VA, Maguiña JL, et al. Prognostic value of neutrophil-to-lymphocyte ratio in COVID-19 patients: A systematic review and meta-analysis. International Journal of Clinical Practice. 2021;75(11):e14596-e.doi : 10.1111/ijcp.14596
Karageorgiou V, Milas GP, Michopoulos I. Neutrophil-to-lymphocyte ratio in schizophrenia: A systematic review and meta-analysis. Schizophrenia research. 2019;206:4-12. doi : 10.1016/j.schres.2018.12.017
Erre GL, Paliogiannis P, Castagna F, Mangoni AA, Carru C, Passiu G, et al. Meta-analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in rheumatoid arthritis. European journal of clinical investigation. 2019;49(1). doi : 10.1111/eci.13877
Li W, Hou M, Ding Z, Liu X, Shao Y, Li X. Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Stroke: A Systematic Review and Meta-Analysis. Frontiers in Neurology. 2021;12:1647-. doi : 10.3389/fneur.2021.686983
Kurtul BE, Ozer PA. Neutrophil-to-lymphocyte ratio in ocular diseases: a systematic review. International Journal of Ophthalmology. 2019;12(12):1951-. doi : 10.18240/ijo.2019.12.18
Vakili S, Torabinavid P, Tabrizi R, Shojazadeh A, Asadi N, Hessami K. The Association of Inflammatory Biomarker of Neutrophil-to-Lymphocyte Ratio with Spontaneous Preterm Delivery: A Systematic Review and Meta-analysis. Mediators of Inflammation. 2021;2021. doi : 10.1155/2021/6668381
Ingersoll J, Halliday M, Adams DJ, Auten JD, Morrison Ponce D. Inflammatory markers limitations in the diagnosis of pediatric calcaneal osteomyelitis. Am J Emerg Med. 2019;37(11):2119.e3-.e5. doi : 10.1016/j.ajem.2019.158416
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Derechos de autor 2024 Alvaro Campos-Aspajo, Daniela Caman-Peña, Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcón-Braga, Melany D. Mosquera-Rojas, Percy Herrera-Añazco, Vicente A. Benites-Zapata
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.