Suplemento con vitamina K para el control metabólico en pacientes con Diabetes Mellitus tipo 2. Revisión Sistemática
DOI:
https://doi.org/10.35434/rcmhnaaa.2022.15Supl.%201.1522Palabras clave:
Diabetes mellitus, Vitamina K, Control metabólico, Glucemia, Perfil lipídicoResumen
Objetivo: Determinar el efecto del suplemento con vitamina K sobre el control metabólico en los pacientes con diabetes mellitus tipo 2. Materiales y métodos: Revisión sistemática de ensayos controlados aleatorizados (ECA) en 5 bases de datos. Dos autores seleccionaron los estudios y extrajeron información. El riesgo de sesgo se evaluó con la herramienta de la colaboración Cochrane. Los desenlaces primarios fueron glucosa plasmática, Colesterol total, LDH y HDL. Utilizamos diferencia de medias (MD) para evaluar el efecto en desenlaces continuos. Usamos el modelo de efectos aleatorios. Resultados: Incluimos 2 ECAs (n=100). La vitamina K redujo los valores de glucosa plasmática, pero esto no fue significativo (MD -14.58; IC95% -35.95 a 6.78; p=0.18) en comparación con el grupo placebo. El suplemento con vitamina K no tuvo efecto significativo en cuanto a los valores de colesterol total (MD -1.22; IC95% -21.02 a 18.57; p=0.90), HDL (MD -3.61; IC95% -18.44 a 11.22; p=0.63) y LDL (MD -0.69; IC95% -5.81 a 4.43; p=0.79) comparado con el grupo placebo. Conclusiones: El uso suplementario de vitamina K no tiene efecto significativo en el control metabólico de pacientes diagnosticados con DM-2.
Palabras clave: Diabetes mellitus; Vitamina K; control metabólico; glucemia; perfil lipídico (Fuente: DeCS-BIREME).
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Organización Mundial de la Salud (OMS) [Internet]. Día mundial de la diabetes. [citado 20 may 2021]. Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/diabetes.
MINSA [Internet]. Boletín epidemiológico del Perú 2019. Volumen 28 - SE 43. [citado 20 may 2021]. Disponible: http://www.dge.gob.pe/portal/docs/vigilancia/boletines/2019/43.pdf
American Diabetes Association. Classification and diagnosis of diabetes: Standards of medical care in diabetes—2018. Diabetes Care. 2018;41(Supplement_1):S13–S27. doi: 10.2337/dc18-S002.
INEI [Internet]. Perú: Enfermedades transmisibles y no transmisibles, 2019. [citado 20 may 2021]. Disponible en: https://proyectos.inei.gob.pe/endes/2019/SALUD/ENFERMEDADES_ENDES_2019.pdf.
American Diabetes Association. Standards of Medical Care in Diabetes—2022 Abridged for Primary Care Providers. Clin Diabetes 2022;40(1):10–38. doi: 10.2337/cd22-as01.
Li Y, Peng Chen J, Duan L, Li S. Effect of Vitamin K2 on Type 2 Diabetes Mellitus: A Review. Diabetes Research and Clinical Practice. 2017;137:39-51. doi: 10.1016/j.diabres.2017.11.020.
Lotfy M, Adeghate J, Kalasz H, Singh J, Adeghate E. Chronic complications of diabetes mellitus: A mini review. Curr Diabetes Rev. 2017;13(1):3-10. doi: 10.2174/1573399812666151016101622.
Punthakee Z, Goldenberg R, Katz P, Committee DCCPGE. Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome. Can J Diabetes. 2018 Apr;42 Suppl 1:S10-S15. doi: 10.1016/j.jcjd.2017.10.003.
Booth SL. Vitamin K: Food composition and dietary intakes. Food Nutr. Res. Food Nutr Res. 2012;56. doi: 10.3402/fnr.v56i0.5505.
Fu X, Harshman SG, Shen X, Haytowitz DB, Karl JP, Wolfe BE, et al. Multiple Vitamin K Forms Exist in Dairy Foods. Curr Dev Nutr. 2017 Jun 1;1(6):e000638. doi: 10.3945/cdn.117.000638.
Dahlberg S, Schott U. Vitamin K and its role in diabetic vascular complications and low-grade inflammation. J Diabetes Treat: JDBT-138. 2018;10(1). doi: 10.29011/2574-7568.%20000038.
Ho HJ, Komai M, Shirakawa H. Beneficial Effects of Vitamin K Status on Glycemic Regulation and Diabetes Mellitus: A Mini-Review. Nutrients. 2020;12(8):2485. doi: 10.3390/nu12082485.
Drucker DJ, Nauck MA. The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368(9548):1696-705. doi: 10.1016/S0140-6736(06)69705-5.
El Asmar MS, Naoum JJ, Arbid EJ. Vitamin k dependent proteins and the role of vitamin k2 in the modulation of vascular calcification: A review. Oman Med J. 2014;29(3):172-7. doi: 10.5001/omj.2014.44.
Thomsen SB, Rathcke CN, Zerahn B, Vestergaard H. Increased levels of the calcification marker matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease. Cardiovasc Diabetol. 2010;9:86. doi: 10.1186/1475-2840-9-86.
Jeannin AC, Salem JE, Massy Z, Aubert CE, Vermeer C, Amouyal C, et al. Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes. PLoS One. 2020;15(2):e0229145. doi: 10.1371/journal.pone.0229145.
Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130(3):456-69. doi: 10.1016/j.cell.2007.05.047.
Zhang Y, Ma C, Zhao J, Xu H, Hou Q, Zhang H. Lactobacillus casei Zhang and vitamin K2 prevent intestinal tumorigenesis in mice via adiponectin-elevated different signaling pathways. Oncotarget. 2017;8(15):24719-24727. doi: 10.18632/oncotarget.15791.
Lihn AS, Pedersen SB, Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes Rev. 2005;6(1):13-21. doi: 10.1111/j.1467-789X.2005.00159.x.
Yamauchi T, Kamon J, Yusuke I, Atsushi T, Takehiko Y, Shunhun K, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423(6941):762-9. doi: 10.1038/nature01705.
Rehman K, Akash MSH. Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked? J Biomed Sci. 2016;23(1):87. doi: 10.1186/s12929-016-0303-y.
Shea MK, Booth SL, Massaro JM, Jacques PF, D'Agostino RB Sr, Dawson-Hughes B, et al. Vitamin K and vitamin D status: Associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol. 2008;167(3):313-20. doi: 10.1093/aje/kwm306.
Karamzad N, Maleki V, Carson-Chahhoud K, Azizi S, Sahebkar A, Gargari BP. A systematic review on the mechanisms of vitamin K effects on the complications of diabetes and pre-diabetes. Biofactors. 2020;46(1):21-37. doi: 10.1002/biof.1569.
Yan MKar-Wai, Khalil H. Vitamin supplements in type 2 diabetes mellitus management: A review. Diabetes & metabolic syndrome. 2017;11(2):S589-S595. doi: 10.1016/j.dsx.2017.04.009.
Hussein AG, Mohamed RH, Shalaby SM, Abd El Motteleb DM. Vitamin K2 alleviates type 2 diabetes in rats by induction of osteocalcin gene expression. Nutrition. 2018;47:33-38. doi: 10.1016/j.nut.2017.09.016.
Dihingia A, Ozah D, Ghosh S, Sarkar A, Baruah PK, Kalita J, et al. Vitamin K1 inversely correlates with glycemia and insulin resistance in patients with type 2 diabetes (T2D) and positively regulates SIRT1/AMPK pathway of glucose metabolism in liver of T2D mice and hepatocytes cultured in high glucose. J Nutr Biochem. 2018;52:103-114. doi: 10.1016/j.jnutbio.2017.09.022.
Dihingia A, Ozah D, Baruah PK, Kalita J, Manna P. Prophylactic role of vitamin K supplementation on vascular inflammation in type 2 diabetes by regulating the NF-κB/Nrf2 pathway: Via activating Gla proteins. Food Func. 2018;9:450–462. doi: 10.1039/C7FO01491K.
Aguayo-Ruiz JI, García-Cobián TA, Pascoe-González S, Sánchez-Enríquez S, Llamas-Covarrubias IM, García-Iglesias T, et al. Effect of supplementation with vitamins D3 and K2 on undercarboxylated osteocalcin and insulin serum levels in patients with type 2 diabetes mellitus: a randomized, double-blind, clinical trial. Diabetol Metab Syndr. 2020;12:73. doi: 10.1186/s13098-020-00580-w.
Karamzad N, Faraji E, Adeli S, Carson-Chahhoud K, Azizi S, Pourghassem Gargari B. Effects of MK-7 Supplementation on Glycemic Status, Anthropometric Indices and Lipid Profile in Patients with Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Metab Syndr Obes. 2020;13:2239-2249. doi: 10.2147/DMSO.S253014.
Shahdadian F, Mohammadi H, Rouhani MH. Effect of Vitamin K Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Clinical Trials. Horm Metab Res. 2018;50(3):227-235. doi: 10.1055/s-0044-100616.
Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. doi: 10.1136/bmj.l4898.
CIOMS [Internet]. Pautas éticas internacionales para la investigación relacionada con la salud con seres humanos. 2018 [citado 20 may 2021]. Disponible en: https://cioms.ch/wp-content/uploads/2018/01/CIOMS-EthicalGuideline_SP_WEB.pdf.
Suksomboon N, Poolsup N, Darli Ko Ko H. Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis. Diabetes Metab Syndr Obes. 2017;10:169-177. doi: 10.2147/DMSO.S137571.
Rasekhi H, Karandish M, Jalali MT, Mohammadshahi M, Zarei M, Saki A, et al. Phylloquinone supplementation improves glycemic status independent of the effects of adiponectin levels in premonopause women with prediabetes: a double-blind randomized controlled clinical trial. J Diabetes Metab Disord. 2015;14(1):1. doi: 10.1186/s40200-014-0127-9.
Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, et al. Effects of vitamin K-2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997;75(2):135-43. doi: 10.1254/jjp.75.135.
Rahimi Sakak F, Moslehi N, Niroomand M, Mirmiran P. Glycemic control improvement in individuals with type 2 diabetes with vitamin K2 supplementation: a randomized controlled trial. Eur J Nutr. 2021;60(5):2495-2506. doi: 10.1007/s00394-020-02419-6.
Santos EAD, Giudici KV, França NAG, Peters BSE, Fisberg RM, Martini LA. Correlations among vitamin K intake, body fat, lipid profile and glucose homeostasis in adults and the elderly. Arch Endocrinol Metab. 2020;64(4):436-444. doi: 10.20945/2359-3997000000230.
Karamali M, Ashrafi M, Razavi M, Jamilian M, Akbari M, Asemi Z. The Effects of Calcium, Vitamins D and K co-Supplementation on Markers of Insulin Metabolism and Lipid Profiles in Vitamin D Deficient Women with Polycystic Ovary Syndrome. Exp Clin Endocrinol Diabetes. 2017;125(5):316-321. doi: 10.1055/s-0043-104530.
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Derechos de autor 2023 Kathleen Condemarin Torres, Victor Hugo Bardales Zuta
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
